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Indian stock markets closed lower on Tuesday's monthly expiry day due to profit booking. The S&P BSE Sensex fell 313.70 points, and the NSE Nifty50 dropped 74.70 points. Analysts cited a weakening INR, FII outflows, and caution ahead of the FOMC meeting as key drivers. While IT and consumer durables saw declines, PSU banks and real estate stocks performed well.